In Vivo Gene Essentiality and Metabolism in Bordetella pertussis.

ABSTRACT: Bordetella pertussis is the causative agent of whooping cough, a serious respiratory illness affecting children and adults, associated with prolonged cough and potential mortality. Whooping cough has reemerged in recent years, emphasizing a need for increased knowledge of basic mechanisms of B. pertussis growth and pathogenicity. While previous studies have provided insight into in vitro gene essentiality of this organism, very little is known about in vivo gene essentiality, a critical gap in knowledge, since B. pertussis has no previously identified environmental reservoir and is isolated from human respiratory tract samples. We hypothesize that the metabolic capabilities of B. pertussis are especially tailored to the respiratory tract and that m

SUBMITTER: Gonyar LA 

PROVIDER: S-EPMC6531889 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature