Glyceryl trinitrate blocks staphyloxanthin and biofilm formation in Staphylococcus aureus.

ABSTRACT:

Background

Staphylococcus aureus is an important nosocomial bacterium that is responsible for a number of infections that may be fatal. The treatment of such infections is limited by emergence of antibiotic resistance. Targeting virulence of Staphylococcus aureus may provide an alternative option to antibiotic that may bypass the emergence of resistant strains due to lack of stress on viability.

Objectives

Investigation of the ability of glyceryl trinitrate (GTN) to inhibit staphyloxanthin, biofilm and tolerance to oxidative stress.

Methods

The disk sensitivity method was used to detect the methicillin resistance of Staphylococcus aureus. The effect of sub-inhibitory concentration of GTN on biofilm formation, staphyloxanthin production and toleran

SUBMITTER: Abbas HA 

PROVIDER: S-EPMC6531949 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature