Characterization of antiviral T cell responses during primary and secondary challenge of laboratory cats with feline infectious peritonitis virus (FIPV).

ABSTRACT:

Background

Feline infectious peritonitis (FIP) is considered highly fatal in its naturally occurring form, although up to 36% of cats resist disease after experimental infection, suggesting that cats in nature may also resist development of FIP in the face of infection with FIP virus (FIPV). Previous experimental FIPV infection studies suggested a role for cell-mediated immunity in resistance to development of FIP. This experimental FIPV infection study in specific pathogen free (SPF) kittens describes longitudinal antiviral T cell responses and clinical outcomes ranging from rapid progression, slow progression, and resistance to disease.

Results

Differences in disease outcome provided an opportunity to investigate the role of T cell immunity to FIP determined by T cell subs

SUBMITTER: Mustaffa-Kamal F 

PROVIDER: S-EPMC6532132 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature