Remote ischemic conditioning in septic shock (RECO-Sepsis): study protocol for a randomized controlled trial.

ABSTRACT:

Background

Septic shock is a major public health problem that is associated with up to 50% mortality. Unfavorable outcomes are mainly attributed to multiple organ failure (MOF) resulting from an uncontrolled inflammatory response and ischemia-reperfusion processes. REmote ischemic COnditioning (RECO) is a promising intervention to prevent ischemia-reperfusion injury. We hypothesize that RECO would reduce the severity of septic shock-induced MOF.

Methods/design

RECO in septic shock patients (RECO-Sepsis study) is an ongoing, prospective, multicenter, randomized, open-label trial, testing whether RECO, as an adjuvant therapy to conventional treatment in septic shock, decreases the severity of MOF as assessed by the Sequential Organ Failure Assessment (SOFA) score. Adult patien

SUBMITTER: Cour M 

PROVIDER: S-EPMC6532140 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature