Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk.

ABSTRACT:

Background

Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important to more accurately predict risk.

Methods

Using 3628 breast cancer cases and 5126 controls of European ancestry from eight case-control studies, we evaluated joint associations of a 77-single nucleotide polymorphism (SNP) PRS and quantitative mammographic density measures with breast cancer. Mammographic percent density and absolute dense area were evaluated using thresholding software and examined as residuals after adjusting for age, 1/BMI, and study. PRS and adjusted density phen

SUBMITTER: Vachon CM 

PROVIDER: S-EPMC6532188 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature