Association of NTCP polymorphisms with clinical outcome of hepatitis B infection in Thai individuals.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) in the sodium taurocholate co-transporting polypeptide (NTCP) have been showed to be associated with natural history of hepatitis B virus (HBV) infection. However, it is unclear whether the SNPs are related to the clinical outcome of HBV infection in Thai individuals.

Methods

The rs2296651 and rs4646287 polymorphisms of NTCP were determined by allelic discrimination using commercial TaqMan probes in blood samples of 1021 Thai individuals. These subjects included 610 patients with chronic HBV infection [CHB, 305 with hepatocellular carcinoma (HCC) and 305 without HCC], 206 subjects with spontaneous HBV clearance and 205 healthy controls who were age and gender-matched.

Results

The frequencies of rs2296651 A minor allele

SUBMITTER: Chuaypen N 

PROVIDER: S-EPMC6532194 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature