Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma.

ABSTRACT:

Background

Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role in processes such as cell growth, angiogenesis and metastasis. In this study, we examined vitronectin expression in neuroblastoma to investigate whether this molecule takes part in cell-cell or cell-extracellular matrix interactions that may confer mechanical properties to promote tumor aggressiveness.

Methods

We used immunohistochemistry and image analysis tools to characterize vitronectin expression and to test its prognostic value in 91 neuroblastoma patients. To better understand the effect of vitronectin, we studied its in vitro expression using commercial neuroblastoma cell lines and in vivo using intra-adrenal gland xenograft models by immunohistochemistry.

SUBMITTER: Burgos-Panadero R 

PROVIDER: S-EPMC6532218 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature