Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study.

ABSTRACT: Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV₁), their ratio (FEV₁/FVC), and forced expiratory flow 25-75% (FEF_25-75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early life risk factors before the age of 10 years were assessed for the trajectories.

Method

Members of the birth cohort (1989/90) were followed at age 1, 2, 4, 10, 18, and 26 years. Allergic sensitization and questionnaire data were collected. Spirometry tests were performed and evaluated according to the American Thoracic Society (ATS) criteria at 10, 18, and 26 years. To identify developmental trajectories for FVC, FEV₁, FEV₁

SUBMITTER: Karmaus W 

PROVIDER: S-EPMC6532227 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature