Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis.

ABSTRACT:

Background

The mechanisms driving multiple sclerosis (MS), the most common cause of non-traumatic disability in young adults, remain unknown despite extensive research. Especially puzzling are the underlying molecular processes behind the two major disease patterns of MS: relapsing-remitting and progressive. The relapsing-remitting course is exemplified by acute inflammatory attacks, whereas progressive MS is characterized by neurodegeneration on a background of mild-moderate inflammation. The molecular and cellular features differentiating the two patterns are still unclear, and the role of inflammation during progressive disease is a subject of active debate.

Methods

We performed a comprehensive analysis of the intrathecal inflammation in two clinically distinct mouse mode

SUBMITTER: DiSano KD 

PROVIDER: S-EPMC6532235 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature