Microbial community drivers of PK/NRP gene diversity in selected global soils.

ABSTRACT:

Background

The emergence of antibiotic-resistant pathogens has created an urgent need for novel antimicrobial treatments. Advances in next-generation sequencing have opened new frontiers for discovery programmes for natural products allowing the exploitation of a larger fraction of the microbial community. Polyketide (PK) and non-ribosomal pepetide (NRP) natural products have been reported to be related to compounds with antimicrobial and anticancer activities. We report here a new culture-independent approach to explore bacterial biosynthetic diversity and determine bacterial phyla in the microbial community associated with PK and NRP diversity in selected soils.

Results

Through amplicon sequencing, we explored the microbial diversity (16S rRNA gene) of 13 soils from Antarc

SUBMITTER: Borsetto C 

PROVIDER: S-EPMC6532259 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature