Ontology highlight
ABSTRACT:
SUBMITTER: Ben Zouari Y
PROVIDER: S-EPMC6532271 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Genome biology 20190522 1
Capture Hi-C (CHi-C) is a new technique for assessing genome organization based on chromosome conformation capture coupled to oligonucleotide capture of regions of interest, such as gene promoters. Chromatin loop detection is challenging because existing Hi-C/4C-like tools, which make different assumptions about the technical biases presented, are often unsuitable. We describe a new approach, ChiCMaxima, which uses local maxima combined with limited filtering to detect DNA looping interactions, ...[more]