Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells.

ABSTRACT:

Purpose

Prostate cancer (PC) is a common malignant tumor and a leading cause of cancer-related death in men worldwide. In order to design new therapeutic interventions for PC, an understanding of the molecular events underlying PC tumorigenesis is required. Bloom syndrome protein (BLM) is a RecQ-like helicase, which helps maintain genetic stability. BLM dysfunction has been implicated in tumor development, most recently during PC tumorigenesis. However, the molecular basis for BLM-induced PC progression remains poorly characterized. In this study, we investigated whether BLM modulates the phosphorylation of an array of prooncogenic signaling pathways to promote PC progression.

Methods

We analyzed differentially expressed proteins (DEPs) using iTRAQ technology. Site-directed

SUBMITTER: Chen K 

PROVIDER: S-EPMC6532288 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature