Parasite resource manipulation drives bimodal variation in infection duration.

ABSTRACT: Over a billion people on earth are infected with helminth parasites and show remarkable variation in parasite burden and chronicity. These parasite distributions are captured well by classic statistics, such as the negative binomial distribution. But the within-host processes underlying this variation are not well understood. In this study, we explain variation in macroparasite infection outcomes on the basis of resource flows within hosts. Resource flows realize the interactions between parasites and host immunity and metabolism. When host metabolism is modulated by parasites, we find a positive feedback of parasites on their own resources. While this positive feedback results in parasites improving their resource availability at high burdens, giving rise to chronic infections, it also re

SUBMITTER: van Leeuwen A 

PROVIDER: S-EPMC6532525 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature