The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.

ABSTRACT: Appropriate immune responses require a fine balance between immune activation and attenuation. NLRC3, a non-inflammasome-forming member of the NLR innate immune receptor family, attenuates inflammation in myeloid cells and proliferation in epithelial cells. T lymphocytes express the highest amounts of Nlrc3 transcript where its physiologic relevance is unknown. We show that NLRC3 attenuated interferon-γ and TNF expression by CD4⁺ T cells and reduced T helper 1 (Th1) and Th17 cell proliferation. Nlrc3^-/- mice exhibited increased and prolonged CD4⁺ T cell responses to lymphocytic choriomeningitis virus infection and worsened experimental autoimmune encephalomyelitis (EAE). These functions of NLRC3 were executed in a T-cell-intrinsic fashion: NLRC3 reduced K63

SUBMITTER: Uchimura T 

PROVIDER: S-EPMC6532657 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature