Heme oxygenase-1 promoter polymorphisms and risk of spina bifida.

ABSTRACT:

Background

Spina bifida is the most common form of neural tube defects (NTDs). Etiologies of NTDs are multifactorial, and oxidative stress is believed to play a key role in NTD development. Heme oxygenase (HO), the rate-limiting enzyme in heme degradation, has multiple protective properties including mediating antioxidant processes, making it an ideal candidate for study. The inducible HO isoform (HO-1) has two functional genetic polymorphisms: (GT)n dinucleotide repeats and A(-413)T SNP (rs2071746), both of which can affect its promoter activity. However, no study has investigated a possible association between HO-1 genetic polymorphisms and risk of NTDs.

Methods

This case-control study included 152 spina bifida cases (all myelomeningoceles) and 148 non-malformed controls o

SUBMITTER: Fujioka K 

PROVIDER: S-EPMC6532789 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature