On the evolutionary ecology of multidrug resistance in bacteria.

ABSTRACT: Resistance against different antibiotics appears on the same bacterial strains more often than expected by chance, leading to high frequencies of multidrug resistance. There are multiple explanations for this observation, but these tend to be specific to subsets of antibiotics and/or bacterial species, whereas the trend is pervasive. Here, we consider the question in terms of strain ecology: explaining why resistance to different antibiotics is often seen on the same strain requires an understanding of the competition between strains with different resistance profiles. This work builds on models originally proposed to explain another aspect of strain competition: the stable coexistence of antibiotic sensitivity and resistance observed in a number of bacterial species. We first identify a p

SUBMITTER: Lehtinen S 

PROVIDER: S-EPMC6532944 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature