Pro- and anti-inflammatory eicosanoids in psoriatic arthritis.

ABSTRACT:

Introduction

Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they might also have a protective function, underscoring the need for a comprehensive understanding of how eicosanoid pathways might be imbalanced. Until recently, sensitive and scalable methods for detecting and quantifying a high number of eicosanoids have not been available.

Objective

Here, we intend to describe a detailed eicosanoid profiling in patients with psoriatic arthritis (PsA) and evaluate correlations with parameters of disease activity.

Methods

Forty-one patients with PsA, all of whom satisfied the CASPAR classification criteria for PsA, were stud

SUBMITTER: Coras R 

PROVIDER: S-EPMC6533065 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature