Gelatin Hydrogel Combined with Polydopamine Coating to Enhance Tissue Integration of Medical Implants.

ABSTRACT: Soft tissue integration of medical implants is important to prevent bacterial infection and implant failure. A bioadhesive that forms firm binding between the implant and the surrounding tissue and facilitates the wound-healing process will be a great tool to establish the desired tissue-implant integration. In this project, we introduce a novel method that can be used to enhance integration between any implant material and any tissue using an enzyme-crosslinked gelatin hydrogel combined with polydopamine (PDA) coating. PDA coating was shown to enhance the binding between the gelatin hydrogel and three model implant materials - aluminum, poly(methyl methacrylate) (PMMA) and titanium. When combined with the gelatin hydrogel, pig cornea tissue adhered more strongly to the PDA coated surfaces

SUBMITTER: Dinh TN 

PROVIDER: S-EPMC6533074 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature