Urinary metabolomics reveals unique metabolic signatures in infants with cystic fibrosis.

ABSTRACT:

Background

Biologic pathways and metabolic mechanisms underpinning early systemic disease in cystic fibrosis (CF) are poorly understood. The Baby Observational and Nutrition Study (BONUS) was a prospective multi-center study of infants with CF with a primary aim to examine the current state of nutrition in the first year of life. Its secondary aim was to prospectively explore concurrent nutritional, metabolic, respiratory, infectious, and inflammatory characteristics associated with early CF anthropometric measurements. We report here metabolomics differences within the urine of these infants as compared to infants without CF.

Methods

Urine metabolomics was performed for 85 infants with predefined clinical phenotypes at approximately one year of age enrolled in BONUS via Ult

SUBMITTER: Kopp BT 

PROVIDER: S-EPMC6533170 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature