Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [¹⁸F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.

ABSTRACT:

Purpose

Previous studies demonstrated the utility of [¹⁸F]fluoropropyl-(+)-dihydrotetrabenazine ([¹⁸F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in healthy control (HC) and type 1 diabetes mellitus (T1DM) groups. Quantification of specific binding requires measurement of non-displaceable uptake. Our goal was to identify a reference tissue (renal cortex or spleen) to quantify pancreatic non-specific binding of [¹⁸F]FP-(+)-DTBZ with the inactive enantiomer, [¹⁸F]FP-(-)-DTBZ. This was the first human study of [¹⁸F]FP-(-)-DTBZ.

Procedures

Six HCs and four T1DM patients were scanned on separate days after injection of [

SUBMITTER: Naganawa M 

PROVIDER: S-EPMC6533199 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature