TSH suppression aggravates arterial inflammation - an ¹⁸F-FDG PET study in thyroid carcinoma patients.

ABSTRACT:

Purpose

We aimed to investigate the influence of both hypothyroidism and thyroid-stimulating hormone (TSH) suppression on vascular inflammation, as assessed with ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT).

Methods

Ten thyroid carcinoma patients underwent an ¹⁸F-FDG PET/CT during post-thyroidectomy hypothyroidism and during thyrotropin (TSH) suppression after ¹³¹I (radioiodine) ablation therapy. We analysed the ¹⁸F-FDG uptake in the carotids, aortic arch, ascending, descending, and abdominal aorta to investigate the effects of thyroid hormone status on arterial inflammation. Target-to-background ratios (TBRs) corrected for blood pool activity were established for all arter

SUBMITTER: Boswijk E 

PROVIDER: S-EPMC6533218 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature