SLC41A1 is essential for magnesium homeostasis in vivo.

ABSTRACT: Solute carrier family 41 member A1 (SLC41A1) has been suggested to mediate magnesium (Mg²⁺) transport by several in vitro studies. However, the physiological function of SLC41A1 remains to be elucidated. In this study, cellular Mg²⁺ transport assays combined with zebrafish slc41a1 knockdown experiments were performed to disclose SLC41A1 function and its physiological relevance. The gene slc41a1 is ubiquitously expressed in zebrafish tissues and is regulated by water and dietary Mg²⁺ availability. Knockdown of slc41a1 in zebrafish larvae grown in a Mg²⁺-free medium resulted in a unique phenotype characterized by a decrease in zebrafish Mg content. This decrease shows that SLC41A1 is required to maintain Mg²⁺ balance and its dysfunction

SUBMITTER: Arjona FJ 

PROVIDER: S-EPMC6533229 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature