Dataset Information

Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.

ABSTRACT: Glutamatergic dysregulation is implicated in the neurobiology of mood disorders. This study investigated the relationship between the anterior cingulate cortex (AC) glutamate, as measured by proton magnetic resonance spectroscopy (1H-MRS), and single-nucleotide polymorphisms (SNPs) from four genes (GLUL, SLC1A3, SLC1A2, and SLC1A7) that regulate the extracellular glutamate in 26 depressed patients with major depressive disorder (MDD; n?=?15) and bipolar disorder (BD; n?=?11). Two SNPs (rs3812778 and rs3829280), in perfect linkage disequilibrium, in the 3' untranslated region of the EAAT2 gene SLC1A2, were associated with AC glutamate, with minor allele carriers having significantly higher glutamate levels (p?

SUBMITTER: Veldic M

PROVIDER: S-EPMC6533282 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.

Veldic Marin M Millischer Vincent V Port John D JD Ho Ada Man-Choi AM Jia Yun-Fang YF Geske Jennifer R JR Biernacka Joanna M JM Backlund Lena L McElroy Susan L SL Bond David J DJ Villaescusa J Carlos JC Skime Michelle M Choi Doo-Sup DS Lavebratt Catharina C Schalling Martin M Frye Mark A MA

Translational psychiatry 20190523 1

Glutamatergic dysregulation is implicated in the neurobiology of mood disorders. This study investigated the relationship between the anterior cingulate cortex (AC) glutamate, as measured by proton magnetic resonance spectroscopy (<sup>1</sup>H-MRS), and single-nucleotide polymorphisms (SNPs) from four genes (GLUL, SLC1A3, SLC1A2, and SLC1A7) that regulate the extracellular glutamate in 26 depressed patients with major depressive disorder (MDD; n = 15) and bipolar disorder (BD; n = 11). Two SNPs ...[more]

PMID: 31123248

Dataset Information

Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.

Publications

Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.

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