Multi-omics Analysis of Liver Infiltrating Macrophages Following Ethanol Consumption.

ABSTRACT: Alcoholic liver disease (ALD) is a significant health hazard and economic burden affecting approximately 10 million people in the United States. ALD stems from the production of toxic-reactive metabolites, oxidative stress and fat accumulation in hepatocytes which ultimately results in hepatocyte death promoting hepatitis and fibrosis deposition. Monocyte-derived infiltrating Ly6C^hi and Ly6C^low macrophages are instrumental in perpetuating and resolving the hepatitis and fibrosis associated with ALD pathogenesis. In the present study we isolated liver infiltrating macrophages from mice on an ethanol diet and subjected them to metabolomic and proteomic analysis to provide a broad assessment of the cellular metabolite and protein differences between infiltrating macropha

SUBMITTER: Marentette JO 

PROVIDER: S-EPMC6533323 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature