Systemic treatment and radiotherapy, breast cancer subtypes, and survival after long-term clinical follow-up.

ABSTRACT:

Background

It remains unclear whether breast cancer subtypes are associated with clinical outcome in patients without any treatment including systemic and radiation therapy as an independent entity. Understanding the survival profiles among subtypes by treatment status could impact optimal selection of treatments.

Methods

Patients were diagnosed with invasive breast cancer from the community hospitals across four geographical regions of the United States. Expression of hormone receptor (HR) and HER2 in tumor specimens from 1169 patients was centrally determined by immunohistochemistry and fluorescence in situ; breast cancer was classified into HR⁺/HER2^-, HR⁺/HER2⁺, triple-negative, and HER2⁺ subtypes. Overall survival (O

SUBMITTER: Yang SX 

PROVIDER: S-EPMC6533413 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature