A high-risk luminal A dominant breast cancer subtype with increased mobility.

ABSTRACT:

Purpose

Breast cancer is a heterogeneous disease, and although advances in molecular subtyping have been achieved in recent years, most subtyping strategies target individual genes independent of one another and primarily concentrate on proliferative markers. The contributions of biological processes and immune patterns have been neglected in breast cancer subtype stratification.

Methods

We performed a gene set variation analysis to simplify the information on biological processes using hallmark terms and to decompose immune cell data using the immune cell gene terms on 985 breast invasive ductal/lobular carcinoma RNAseq samples in the TCGA database.

Results

The samples were gathered into three clusters following implementation of the t-SNE and DBSCAN algorithms and w

SUBMITTER: Guo L 

PROVIDER: S-EPMC6533414 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature