Fluid volume kinetics of 20% albumin.

ABSTRACT:

Aims

A population kinetic model was developed for the body fluid shifts occurring when 20% albumin is given by intravenous infusion. The aim was to study whether its efficacy to expand the plasma volume is impaired after major surgery.

Methods

An intravenous infusion of 3 mL/kg 20% albumin over 30 minutes was given to 15 volunteers and to 15 patients on the 1^st day after major open abdominal surgery. Blood samples and urine were collected during 5 hours. Mixed-effect modelling software was used to develop a fluid volume kinetic model, using blood haemoglobin and urine excretion the estimate body fluid shifts, to which individual-specific covariates were added in sequence.

Results

The rise in plasma albumin expanded the plasma volume in excess of the infused

SUBMITTER: Hahn RG 

PROVIDER: S-EPMC6533427 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature