Use of CT Imaging to Quantify Progression and Response to Treatment in Lymphangioleiomyomatosis.

ABSTRACT:

Background

In lymphangioleiomyomatosis (LAM), infiltration of the lungs with smooth muscle-like LAM cells results in cystic destruction and decline in lung function, effects stabilized by sirolimus therapy. LAM lung disease is followed, in part, by high-resolution CT scans. To obtain further information from these scans, we quantified changes in lung parenchyma by analyzing image "texture."

Methods

Twenty-six texture properties were quantified by analyzing the distribution and intensity of pixels with a computer-aided system. Both cross-sectional and longitudinal studies were performed to examine the relationships between texture properties, cyst score (percentage of lung occupied by cysts), FEV₁, and diffusion capacity for carbon monoxide (Dlco), and to determine

SUBMITTER: Gopalakrishnan V 

PROVIDER: S-EPMC6533448 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature