ED Door-to-Antibiotic Time and Long-term Mortality in Sepsis.

ABSTRACT:

Background

The impact of antibiotic timing on sepsis outcomes remains controversial due to conflicting results from previous studies.

Objectives

This study investigated the association of door-to-antibiotic time with long-term mortality in ED patients with sepsis.

Methods

This retrospective cohort study included nontrauma adult ED patients with clinical sepsis admitted to four hospitals from 2013 to 2017. Only patients' first eligible encounter was included. Multivariable logistic regression was used to measure the adjusted association between door-to-antibiotic time and 1-year mortality. Secondary analyses used alternative antibiotic timing measures (antibiotic initiation within 1 or 3 h and separate comparison of antibiotic exposure at each hour up to hour 6), alter

SUBMITTER: Peltan ID 

PROVIDER: S-EPMC6533450 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature