Determinants of the interindividual variability in serum cytidine deaminase activity of patients with solid tumours.

ABSTRACT:

Aims

Cytidine deaminase (CDA) activity in cancer patients' serum has been proposed as a predictive biomarker for efficacy and toxicity of nucleoside analogues. However, discrepant results about its predictive value have been reported due to the high interindividual variability in CDA activity. This study aimed at identifying determinants of this interindividual variability.

Methods

From December 2014 to November 2015, 183 patients were prospectively included. Serum CDA activity, biological and clinical characteristics as well as five common single nucleotide polymorphisms (SNPs) in the CDA gene (c.-451C > T, c.-92A > G, c.-33_-31delC, c.79A > C, c.435 T > C) were analysed. Associations between clinical characteristics, pharmacogenetic variants and CDA activity were univariat

SUBMITTER: Cohen R 

PROVIDER: S-EPMC6533495 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature