Identifying gene-environment interactions incorporating prior information.

ABSTRACT: For many complex diseases, gene-environment (G-E) interactions have independent contributions beyond the main G and E effects. Despite extensive effort, it still remains challenging to identify G-E interactions. With the long accumulation of experiments and data, for many biomedical problems of common interest, there are existing studies that can be relevant and informative for the identification of G-E interactions and/or main effects. In this study, our goal is to identify G-E interactions (as well as their corresponding main G effects) under a joint statistical modeling framework. Significantly advancing from the existing studies, a quasi-likelihood-based approach is developed to incorporate information mined from the existing literature. A penalization approach is adopted for identific

SUBMITTER: Wang X 

PROVIDER: S-EPMC6533537 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature