Ontology highlight
ABSTRACT:
SUBMITTER: Shah V
PROVIDER: S-EPMC6533595 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Blood 20181029 23
Multiple myeloma (MM) is a genetically heterogeneous cancer of bone marrow plasma cells with variable outcome. To assess the prognostic relevance of clonal heterogeneity of <i>TP53</i> copy number, we profiled tumors from 1777 newly diagnosed Myeloma XI trial patients with multiplex ligation-dependent probe amplification (MLPA). Subclonal <i>TP53</i> deletions were independently associated with shorter overall survival, with a hazard ratio of 1.8 (95% confidence interval, 1.2-2.8; <i>P</i> = .01 ...[more]