Impact of postoperative radiation therapy for deeply invasive oral cavity cancer upstaged to stage III.

ABSTRACT:

Background

This article is about the eighth edition staging guidelines for upstaged patients with oral cavity squamous cell carcinoma (OCSCC) with >10 mm depth to pT3. This upstages some patients from stage I-II to stage III, a point at which patients are traditionally considered for postoperative radiation therapy (PORT). The role of PORT in patients upstaged for >10 mm depth is unknown.

Methods

We identified patients with surgically resected stage I-II OCSCC with >10 mm depth who were upstaged to stage III. We used Cox proportional hazard modeling to compare patients who received PORT to those who did not (median follow-up 38.6 months).

Results

We observed that 3.6% of patients with OCSCC were upstaged to stage III for depth >10 mm including 823 eligible patients. O

SUBMITTER: Cramer JD 

PROVIDER: S-EPMC6533633 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature