Circulating miRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy.

ABSTRACT:

Background

Prostate cancer is an extremely heterogeneous disease. Despite being clinically similar, some tumours are more likely to recur after surgery compared to others. Distinguishing those that need adjuvant or salvage radiotherapy will improve patient outcomes. The goal of this study was to identify circulating microRNA that could independently predict prostate cancer patient risk stratification after radical prostatectomy.

Methods

Seventy-eight prostate cancer patients were recruited at the Odette Cancer Centre in Sunnybrook Health Sciences Centre. All patients had previously undergone radical prostatectomy. Blood samples were collected simultaneously for PSA testing and miRNA analysis using NanoString nCounter technology. Of the 78 samples, 75 had acceptable miRNA qua

SUBMITTER: Hoey C 

PROVIDER: S-EPMC6533745 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature