GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.

ABSTRACT: Purpose: GPR158 is a newly characterized family C G-protein-coupled receptor, previously identified in functional screens linked with biological stress, including one for susceptibility to ocular hypertension/glaucoma induced by glucocorticoid stress hormones. In this study, we investigated GPR158 function in the visual system. Methods: Gene expression and protein immunolocalization analyses were performed in mouse and human brain and eye to identify tissues where GPR158 might function. Gene expression was perturbed in mice, and in cultures of human trabecular meshwork cells of the aqueous outflow pathway, to investigate function and mechanism. Results:GPR158 is highly expressed in the brain, and in this study, we show prominent expression s

SUBMITTER: Itakura T 

PROVIDER: S-EPMC6533807 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature