Cognitive consequences of regression of cerebral small vessel disease.

ABSTRACT:

Introduction

Recent studies have shown that neuroimaging markers of cerebral small vessel disease can also regress over time. We investigated the cognitive consequences of regression of small vessel disease markers.

Patients and methods

Two hundred and seventy-six participants of the RUNDMC study underwent neuroimaging and cognitive assessments at three time-points over 8.7 years. We semi-automatically assessed white matter hyperintensities volumes and manually rated lacunes and microbleeds. We analysed differences in cognitive decline and accompanying brain atrophy between participants with regression, progression and stable small vessel disease by analysis of variance.

Results

Fifty-six participants (20.3%) showed regression of small vessel disease markers: 31 (11.2

SUBMITTER: van Leijsen EM 

PROVIDER: S-EPMC6533868 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature