Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the most common cause of dementia worldwide, normally affecting people aged over 65. Due to the multifactorial nature of this disease, a "multi-target-directed ligands" (MTDLs) approach for the treatment of this illness has generated intense research interest in the past few years. Vanillin is a natural antioxidant and it provides a good starting point for the synthesis of new compounds with enhanced antioxidant properties, together with many biological activities, including β-amyloid peptide aggregating and acetylcholinesterase inhibiting properties. Here we report novel vanillin derivatives, bearing a tacrine or a naphthalimido moiety. All compounds exhibited improved antioxidant properties using DPPH assay, with IC₅₀ as low as 19.5 μM, FRAP and ORA

SUBMITTER: Scipioni M 

PROVIDER: S-EPMC6533886 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature