CD8⁺ T cells regulate tumour ferroptosis during cancer immunotherapy.

ABSTRACT: Cancer immunotherapy restores or enhances the effector function of CD8⁺ T cells in the tumour microenvironment^1,2. CD8⁺ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin-granzyme and Fas-Fas ligand pathways^3,4. Ferroptosis is a form of cell death that differs from apoptosis and results from iron-dependent accumulation of lipid peroxide^5,6. Although it has been investigated in vitro^7,8, there is emerging evidence that ferroptosis might be implicated in a variety of pathological scenarios^9,10. It is unclear whether, and how, ferroptosis is involved in T cell immunity and cancer immunotherapy. Here we show that immunotherapy-activated CD8⁺ T cells enhanc

SUBMITTER: Wang W 

PROVIDER: S-EPMC6533917 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature