Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells.

ABSTRACT: NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in IAV and other respiratory viral infections. Here, we investigated the effects of IAV infection on human lung and peripheral blood NK cells in vitro and ex vivo following clinical infection. IAV infection of lung- and peripheral blood-derived mononuclear cells in vitro induced NK cell hyperresponsiveness to K562 target cells, including increased degranulation and cytokine production particularly in the CD56^brightCD16^- subset of NK cells. Furthermore, lung CD16^- NK cells showed increased IAV-mediated but target cell-independent activation co

SUBMITTER: Scharenberg M 

PROVIDER: S-EPMC6534051 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature