Considering Genetic Heterogeneity in the Association Analysis Finds Genes Associated With Nicotine Dependence.

ABSTRACT: While substantial progress has been made in finding genetic variants associated with nicotine dependence (ND), a large proportion of the genetic variants remain undiscovered. The current research focuses have shifted toward uncovering rare variants, gene-gene/gene-environment interactions, and structural variations predisposing to ND, the impact of genetic heterogeneity in ND has been nevertheless paid less attention. The study of genetic heterogeneity in ND not only could enhance the power of detecting genetic variants with heterogeneous effects in the population but also improve our understanding of genetic etiology of ND. As an initial step to understand genetic heterogeneity in ND, we applied a newly developed heterogeneity weighted U (HWU) method to 26 ND-related genes, investigating

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6534062 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature