Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction.

ABSTRACT: The interaction between gut microbiota and host plays a central role in health. Dysbiosis, detrimental changes in gut microbiota and inflammation have been reported in non-communicable diseases. While diet has a profound impact on gut microbiota composition and function, the role of food additives such as titanium dioxide (TiO₂), prevalent in processed food, is less established. In this project, we investigated the impact of food grade TiO₂ on gut microbiota of mice when orally administered via drinking water. While TiO₂ had minimal impact on the composition of the microbiota in the small intestine and colon, we found that TiO₂ treatment could alter the release of bacterial metabolites in vivo and affect the spatial distribution of commens

SUBMITTER: Pinget G 

PROVIDER: S-EPMC6534185 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature