Parent-offspring transmission of drug abuse and alcohol use disorder: Application of the multiple parenting relationships design.

ABSTRACT: With complete genealogical and cohabitation information, new genetic-epidemiological designs can be developed to clarify causes of parent-offspring transmission. We propose the Multiple Parenting Relationships (MPR) Design and apply it to drug abuse (DA) and alcohol use disorder (AUD). Using national Swedish registries, we identified four kinds of informative parents with multiple children with whom they had different genetic and/or rearing relationships. These types had children for whom they provided: (a) genes (G) plus rearing (R), G only and R only; (b) G + R and G only; (c) G only and R only; and (d) G + R and R only. We identified DA and AUD cases from national registries in over 475,000 informative parent-offspring pairs. Controlling for parental resemblance for DA or AUD, all estim

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC6534277 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature