The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria.

ABSTRACT:

Background

Chemotherapy is a principle tool for the control and prevention of piroplasmosis. The search for a new chemotherapy against Babesia and Theileria parasites has become increasingly urgent due to the toxic side effects of and developed resistance to the current drugs. Chalcones have attracted much attention due to their diverse biological activities. With the aim to discover new drugs and drug targets, in vitro and in vivo antibabesial activity of trans-chalcone (TC) and chalcone 4 hydrate (CH) alone and combined with diminazene aceturate (DA), clofazimine (CF) and atovaquone (AQ) were investigated.

Methodology/principal findings

The fluorescence-based assay was used for evaluating the inhibitory effect of TC and CH on four Babesia species, including B. bovis, B. bi

SUBMITTER: Batiha GE 

PROVIDER: S-EPMC6534319 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature