Delivery of different genes into pre- and post-synaptic neocortical interneurons connected by GABAergic synapses.

ABSTRACT: Local neocortical circuits play critical roles in information processing, including synaptic plasticity, circuit physiology, and learning, and GABAergic inhibitory interneurons have key roles in these circuits. Moreover, specific neurological disorders, including schizophrenia and autism, are associated with deficits in GABAergic transmission in these circuits. GABAergic synapses represent a small fraction of neocortical synapses, and are embedded in complex local circuits that contain many neuron and synapse types. Thus, it is challenging to study the physiological roles of GABAergic inhibitory interneurons and their synapses, and to develop treatments for the specific disorders caused by dysfunction at these GABAergic synapses. To these ends, we report a novel technology that can deliver

SUBMITTER: Nagayach A 

PROVIDER: S-EPMC6534327 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature