Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil.

ABSTRACT:

Background

Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies.

Objectives

The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children.

Methods

A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated.

Findings

No associations

SUBMITTER: Ornelas AMM 

PROVIDER: S-EPMC6534340 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature