Synergistic effects of laminin-1 peptides, VEGF and FGF9 on salivary gland regeneration.

ABSTRACT: Hyposalivation is associated with radiation therapy, Sjögren's syndrome and/or aging, and is a significant clinical problem that decreases oral health and overall health in many patients and currently lacks effective treatment. Hence, methods to regenerate salivary glands and restore saliva secretion are urgently needed. To this end, this study describes the modification of fibrin hydrogels with a combination of laminin-1 peptides (YIGSR and A99) and human growth factors (vascular endothelial growth factor and fibroblast growth factor 9) to enhance regeneration in a salivary gland injury mouse model. Our results indicate that these fortified hydrogels enhanced angiogenesis and neurogenesis while promoting formation of acinar structures, thereby leading to enhanced saliva secretion. Such fu

SUBMITTER: Nam K 

PROVIDER: S-EPMC6534356 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature