Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population.

ABSTRACT:

Background

Altered striatal development contributes to core deficits in motor and inhibitory control, impulsivity, and inattention associated with attention-deficit/hyperactivity disorder and may likewise play a role in deficient reward processing and emotion regulation in psychosis and depression. The maturation of striatal connectivity has not been well characterized, particularly as it relates to clinical symptomatology.

Methods

Resting-state functional connectivity with striatal subdivisions was examined for 926 participants (8-22 years of age, 44% male) from the general population who had participated in two large cross-sectional studies. Developing circuits were identified and growth charting of age-related connections was performed to obtain individual scores reflecti

SUBMITTER: Barber AD 

PROVIDER: S-EPMC6534442 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature