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Infectivity of GII.4 human norovirus does not differ between T-B-NK⁺ severe combined immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection.

ABSTRACT: Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. It is unclear which arm of the immune system regulates resistance to HuNoV infection. Thus, we studied the pathogenesis of human norovirus (HuNoV) in T^-B^-NK⁺ Severe Combined Immunodeficiency (SCID) gnotobiotic pigs to investigate the role of innate (especially, natural killer (NK) cells) immunity in HuNoV infection. Forty SCID and non-SCID pigs were randomly grouped: 1) SCID+HuNoV (n = 12); 2) non-SCID+HuNoV (n = 14); 3) SCID mock-inoculated (n = 6); and 4) non-SCID mock-inoculated (n = 8). Pigs (8-14-day-old) were inoculated orally with GII.4 HuNoV strain HS292 (mean 9.1 log₁₀ genomic equivalents/pig) or mock. Daily fecal consistency and fecal viral RNA shedding,

SUBMITTER: Annamalai T

PROVIDER: S-EPMC6534450 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Infectivity of GII.4 human norovirus does not differ between T-B-NK⁺ severe combined immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Infectivity of GII.4 human norovirus does not differ between T-B-NK+ severe combined immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Infectivity of GII.4 human norovirus does not differ between T-B-NK⁺ severe combined immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection.