Dose-dependent effects of chronic alcohol drinking on peripheral immune responses.

ABSTRACT: It is well established that chronic heavy alcohol drinking (CHD) results in significant organ damage, increased susceptibility to infections, and poor outcomes following injury. In contrast, chronic moderate drinking (CMD) has been associated with improved cardiovascular health and immunity. These differential outcomes have been linked to alterations in both innate and adaptive branches of the immune system; however, the mechanisms remain poorly understood. To address this question, we determined the impact of chronic drinking on the transcriptional and functional responses of peripheral blood mononuclear cells (PBMC) collected from male rhesus macaques classified as CMD or CHD after 12 months of voluntary ethanol self-administration. Our analysis suggests that chronic alcohol drinking, re

SUBMITTER: Sureshchandra S 

PROVIDER: S-EPMC6534547 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature