Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.

ABSTRACT: Mild-cognitive impairment (MCI) occurs in up to one-fifth of individuals over the age of 65, with approximately a third of MCI individuals converting to dementia in later life. There is a growing necessity for early identification for those at risk of dementia as pathological processes begin decades before onset of symptoms. A cohort of 122 individuals diagnosed with MCI and followed up for a 36-month period for conversion to late-onset Alzheimer's disease (LOAD) were genotyped on the NeuroChip array along with pathologically confirmed cases of LOAD and cognitively normal controls. Polygenic risk scores (PRS) for each individual were generated using PRSice-2, derived from summary statistics produced from the International Genomics of Alzheimer's Disease Project (IGAP) genome-wide associati

SUBMITTER: Chaudhury S 

PROVIDER: S-EPMC6534556 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature